Latin American initiative for lifestyle intervention to prevent cognitive decline (LatAm-FINGERS): study design and harmonization
Fecha
2023-05-19Autor
Crivelli, Lucia
Calandri, Luis
Kimie Suemoto, Claudia
Salinas, Rosa María
Velilla, Lina Marcela
Sanches Yassuda, Mônica
Caramelli, Paulo
Lopera, Francisco
Nitrini, Ricardo
Sevlever, Gustavo Emilio
Sosa, Ana Luisa
Acosta, Daisy
Charamelo Baietti, Ana María
Cusicanqui, María Isabel
Custodio, Nilton
De Simone, Sergio Dansilio
Delgado Derio, Carolina
Duque-Peñailillo, Lissette
Duran, Juan Carlos
Jiménez-Velázquez, Ivonne Z.
Leon-Salas, Jorge Mario
Bergamo, Yanina
Florencia Clarens, María
Damian, Andrés
Demey, Ignacio
Belén Helou, María
Márquez, Carlos
Martin, María Eugenia
Morais Martin, Maria da Graça
Querze, Diego
Surace, Ezequiel Ignacio
Acosta-Egea, Sabrina
Aguirre–Salvador, Esteban
da Cunha Peixoto Cançado, Gustavo Henrique
Dozzi Brucki
Dozzi Brucki, Sonia Maria
Vasconcelos Friedlaender, Clarisse
Braga Gomes, Karina
Gutierrez, Myriam
Laforcada Ríos, Carlos
Martinez Galindo, Joyce Graciela
Montesinos, Rosa
Nuñez-Herrera, Alberto
Ospina-Henao, Sebastián
Rodríguez, Guillermina
Ruiz Masson, Victoria
Sánchez, Mónica
Christian E. Schenk, Christian
Soto, Ligia
Tonidandel Barbosa, Maira
Gonçalves Tosatti, Jéssica Abdo
Vicuña, Yosselin
Espeland, Mark
Hakansson, Krister
Kivipelto, Miia
Baker, Laura
Snyder, Heather
Carrillo, María
Allegri, Ricardo Francisco
Metadatos
Mostrar el registro completo del ítemResumen
Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS) is the first non-pharmacological multicenter randomized clinical trial (RCT) to prevent cognitive impairment in Latin America (LA). Our aim is to present the study design and discuss the strategies used for multicultural harmonization. This 1-year RCT (working on a 1-year extension) investigates the feasibility of a multi-domain lifestyle intervention in LA and the efficacy of the intervention, primarily on cognitive function. An external harmonization process was carried out to follow the FINGER model, and an internal harmonization was performed to ensure this study was feasible and comparable across the 12 participating LA countries. Currently, 1549 participants have been screened, and 815 randomized. Participants are ethnically diverse (56% are Nestizo) and have high cardiovascular risk (39% have metabolic syndrome). LatAm-FINGERS overcame a significant challenge to combine the region's diversity into a multi-domain risk reduction intervention feasible across LA while preserving the original finger design.
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