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Apolipoprotein E (APOE) genotype, dementia, and memory performance among Caribbean Hispanic versus US populations
(Alzheimer's Association, 2022-06-04)
Apolipoprotein E (APOE) is considered the major susceptibility gene for developing Alzheimer's disease. However, the strength of this risk factor is not well established across diverse Hispanic populations. We investigated ...
Latin American initiative for lifestyle intervention to prevent cognitive decline (LatAm-FINGERS): study design and harmonization
(Alzheimer's Association®, 2023-05-19)
Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS) is the first non-pharmacological multicenter randomized clinical trial (RCT) to prevent cognitive impairment in Latin America ...
Interpretable Classification of Tauopathies with a Convolutional Neural Network Pipeline Using Transfer Learning and Validation against Post-Mortem Clinical Cases of Alzheimer’s Disease and Progressive Supranuclear Palsy
(MDP, 2022-11-22)
Neurodegenerative diseases, tauopathies, constitute a serious global health problem.
The etiology of these diseases is unclear and an increase in their incidence has been projected
in the next 30 years. Therefore, the ...
Alzheimer’s disease: an updated overview of its genetics
(International Journal o f Molecular Sciences, 2023-02-13)
Alzheimer’s disease (AD) is the most common neurodegenerative disease in the world. It
is classified as familial and sporadic. The dominant familial or autosomal presentation represents
1–5% of the total number of cases. ...
Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer’s disease
(Acta Neuropathologica, 2024-03)
The risk of developing Alzheimer’s disease (AD) significantly increases in individuals carrying the APOEε4 allele. Elderly
cognitively healthy individuals with APOEε4 also exist, suggesting the presence of cellular ...