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Monitoring temporal changes in SARS-CoV-2 spike antibody levels and variant-specific risk for infection, Dominican Republic, March 2021–August 2022
dc.contributor.author | Nilles, Eric J. | |
dc.contributor.author | de St. Aubin, Michael | |
dc.contributor.author | Dumas, Devan | |
dc.contributor.author | Duke, William | |
dc.contributor.author | Etienne, Marie Caroline | |
dc.contributor.author | Abdalla, Gabriela | |
dc.contributor.author | Jarolim, Petr | |
dc.contributor.author | Oasan, Timothy | |
dc.contributor.author | Garnier, Salome | |
dc.contributor.author | Iihoshi, Naomi | |
dc.contributor.author | Lopez, Beatriz | |
dc.contributor.author | de la Cruz, Lucia | |
dc.contributor.author | Cornelio Puello, Yosanly | |
dc.contributor.author | Baldwin, Margaret | |
dc.contributor.author | Roberts, Kathryn W. | |
dc.contributor.author | Peña, Farah | |
dc.contributor.author | Durski, Kara | |
dc.contributor.author | Sanchez, Isaac Miguel | |
dc.contributor.author | Gunter, Sarah M. | |
dc.contributor.author | Kneubehl, Alexander R. | |
dc.contributor.author | Murray, Kristy O. | |
dc.contributor.author | Lino, Allison | |
dc.contributor.author | Strobel, Sarah | |
dc.contributor.author | Baez, Amado Alejandro | |
dc.contributor.author | Lau, Colleen L. | |
dc.contributor.author | Kucharski, Adam | |
dc.contributor.author | Kucharski, Adam | |
dc.contributor.author | Zielinski Gutiérrez, Emily | |
dc.contributor.author | Skewes-Ramm, Ronald | |
dc.contributor.author | Vasquez, Marietta | |
dc.contributor.author | Then Paulino, Cecilia | |
dc.date.accessioned | 2023-09-03T23:43:54Z | |
dc.date.available | 2023-09-03T23:43:54Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Nilles, E. J., de St. Aubin, M., Dumas, D., Duke, W., Etienne, M., Abdalla, G....Paulino, C. (2023). Monitoring temporal changes in SARS-CoV-2 spike antibody levels and variant-specific risk for infection, Dominican Republic, March 2021–August 2022. Emerging Infectious Diseases, 29(4), 723-733. https://doi.org/10.3201/eid2904.221628. | en_US |
dc.identifier.uri | https://repositorio.unphu.edu.do/handle/123456789/5262 | |
dc.description.abstract | To assess changes in SARS-CoV-2 spike binding antibody prevalence in the Dominican Republic and implications for immunologic protection against variants of concern, we prospectively enrolled 2,300 patients with undifferentiated febrile illnesses in a study during March 2021–August 2022. We tested serum samples for spike antibodies and tested nasopharyngeal samples for acute SARS-CoV-2 infection using a reverse transcription PCR nucleic acid amplification test. Geometric mean spike antibody titers increased from 6.6 (95% CI 5.1–8.7) binding antibody units (BAU)/mL during March–June 2021 to 1,332 (95% CI 1,055–1,682) BAU/mL during May– August 2022. Multivariable binomial odds ratios for acute infection were 0.55 (95% CI 0.40–0.74), 0.38 (95% CI 0.27–0.55), and 0.27 (95% CI 0.18–0.40) for the second, third, and fourth versus the first anti-spike quartile; findings were similar by viral strain. Combining serologic and virologic screening might enable monitoring of discrete population immunologic markers and their implications for emergent variant transmission | en_US |
dc.language.iso | en | en_US |
dc.publisher | RESEARCH | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | COVID-19 | en_US |
dc.subject | Coronavirus | en_US |
dc.subject | Anticuerpos | en_US |
dc.subject | República Dominicana | en_US |
dc.title | Monitoring temporal changes in SARS-CoV-2 spike antibody levels and variant-specific risk for infection, Dominican Republic, March 2021–August 2022 | en_US |
dc.type | Article | en_US |