dc.contributor.author | Peterson, R. E. | |
dc.contributor.author | Imperato-Mcginley, Julianne | |
dc.contributor.author | Gautier, Teófilo | |
dc.contributor.author | Shackleton, C. | |
dc.date.accessioned | 2023-11-20T02:14:29Z | |
dc.date.available | 2023-11-20T02:14:29Z | |
dc.date.issued | 1985-07 | |
dc.identifier.citation | Peterson RE, Imperato-McGinley J, Gautier T, Shackleton C. Urinary steroid metabolites in subjects with male pseudohermaphroditism due to 5 alpha-reductase deficiency. Clin Endocrinol (Oxf). 1985 Jul;23(1):43-53. doi: 10.1111/j.1365-2265.1985.tb00181.x. PMID: 4028464https://doi.org/10.1111/j.1365-2265.1985.tb00181.x | en_US |
dc.identifier.uri | https://repositorio.unphu.edu.do/handle/123456789/5375 | |
dc.description.abstract | To investigate the enzymatic basis for abnormal steroid metabolism in subjects with male pseudohermaphroditism due to 5α-reductase deficiency, the ring A reduced urinary 5β and 5α metabolites of testosterone, androstenedione, 11β-hydroxyandrostenedione, cortisol and corticosterone were measured by gas chromatography. Assays of the four pairs of urinary 5β and 5α steroid metabolites revealed decreased conversion of the parent steroids to 5α-reduced urinary metabolites, with increased 5β to 5α urinary steroid metabolite ratios. These studies establish that increased urinary 5β/5α ratios are distinctive for this disorder, and represent the most reliable method for confirming the diagnosis of primary inherited 5α-reductase deficiency. These data also suggest that the conversion on the many Δ4-3 ketosteroids to 5α-reduced steroids may be due to a single enzyme with broad specificity, or multiple enzyme reductases with a common regulator. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Trastorno del desarrollo sexual 46,XY | en_US |
dc.subject | Trastornos del desarrollo sexual | en_US |
dc.subject | Trastornos ovotesticulares del desarrollo sexual | en_US |
dc.title | Urinary steroid metabolites in subjects with male pseudohermaphroditism due to 5α-reductase deficiency | en_US |
dc.type | Article | en_US |