Listar por autor "Pacheco-Herrero, Mar"
Mostrando ítems 1-8 de 8
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Alzheimer’s disease: an updated overview of its genetics
(International Journal o f Molecular Sciences, 2023-02-13)Alzheimer’s disease (AD) is the most common neurodegenerative disease in the world. It is classified as familial and sporadic. The dominant familial or autosomal presentation represents 1–5% of the total number of cases. ... -
Autophagy: A key regulator of homeostasis and disease: an overview of molecular mechanisms and modulators
(Cells., 2022-08-22)Autophagy is a highly conserved lysosomal degradation pathway active at basal levels in all cells. However, under stress conditions, such as a lack of nutrients or trophic factors, it works as a survival mechanism that ... -
Autophagy: A Key Regulator of Homeostasis and Disease: An Overview of Molecular Mechanisms and Modulators
(Cells, 2022)Autophagy is a highly conserved lysosomal degradation pathway active at basal levels in all cells. However, under stress conditions, such as a lack of nutrients or trophic factors, it works as a survival mechanism that ... -
Biomarker Candidates for Alzheimer’s Disease Unraveled through In Silico Differential Gene Expression Analysis
(Basel, 2022-05-07)Alzheimer’s disease (AD) is neurodegeneration that accounts for 60–70% of dementia cases. Symptoms begin with mild memory difficulties and evolve towards cognitive impairment. The underlying risk factors remain primarily ... -
Mechanistic Insight from Preclinical Models of Parkinson’s Disease Could Help Redirect Clinical Trial Efforts in GDNF Therapy
(Int. J. Mol. Sci, 2021)Parkinson’s disease (PD) is characterized by four pathognomonic hallmarks: (1) motor and non-motor deficits; (2) neuroinflammation and oxidative stress; (3) pathological aggregates of the α-synuclein (α-syn) protein; (4) ... -
Molecular Processing of Tau Protein in Progressive Supranuclear Palsy: Neuronal and Glial Degeneration
(IOS Press BV, 2021)Alzheimer's disease (AD) and progressive supranuclear palsy (PSP) are examples of neurodegenerative diseases, characterized by abnormal tau inclusions, that are called tauopathies. AD is characterized by highly insoluble ... -
The neurovascular unit dysfunction in Alzheimer’s disease
(International Journal o f Molecular Sciences, 2021-02-16)Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide. Histopathologically, AD presents with two hallmarks: neurofibrillary tangles (NFTs), and aggregates of amyloid peptide (A ) both in the ... -
Oxidative stress and mitochondrial complex I dysfunction correlate with neurodegeneration in an -synucleinopathy animal model
(International Journal o f Molecular Sciences Article, 2022-09-27)The α-synucleinopathies constitute a subset of neurodegenerative disorders, of which Parkinson's disease (PD) is the most common worldwide, characterized by the accumulation of misfolded α-synuclein in the cytoplasm of ...