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The impact of COVID19 on Mental Health in the Hispanic Caribbean Region 2020
(International Psychogeriatric, 2020)
The recent global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic will leave its shadow over mental health in our society, especially among the most vulnerable such as elderly populations and those ...
The neurovascular unit dysfunction in Alzheimer’s disease
(International Journal o f Molecular Sciences, 2021-02-16)
Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide.
Histopathologically, AD presents with two hallmarks: neurofibrillary tangles (NFTs), and aggregates
of amyloid peptide (A ) both in the ...
Insoluble vascular amyloid deposits trigger disruption of the neurovascular unit in Alzheimer’s disease brains.
(Int. J. Mol. Sci, 2021-04-01)
Alzheimer’s disease (AD) is a neurodegenerative disease, characterized histopathologically
by intra-neuronal tau-related lesions and by the accumulation of amyloid -peptide (A ) in the brain
parenchyma and around cerebral ...
Current status and challenges of stem cell treatment for Alzheimer’s disease
(Journal of Alzheimer’s Disease, 2021)
Neurodegenerative diseases called tauopathies, such as Alzheimer’s disease (AD), frontotemporal dementia, progressive supranuclear palsy, and Parkinson’s disease, among others, are characterized by the pathological processing ...
Prediction of dementia risk in low-income and middleincome countries (the 10/66 Study): an independent external validation of existing models
(Elsevier Ltd., 2020-04)
To date, dementia prediction models have been exclusively developed and tested in high-income countries (HICs). However, most people with dementia live in low-income and middle-income countries (LMICs), where dementia risk ...
Dementia attributable healthcare utilizations in the Caribbean versus United States
(Journal of Alzheimer's Disease, 2023-11-07)
Despite the high burden of Alzheimer's disease and other dementias among the Hispanic population worldwide, little is known about how dementia affects healthcare utilizations among this population outside of the US, in ...
FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer’s disease
(Acta Neuropathologica (2022) 144:59–79, 2022-05-24)
Alzheimer’s disease (AD) has been associated with cardiovascular and cerebrovascular risk factors (CVRFs) during middle
age and later and is frequently accompanied by cerebrovascular pathology at death. An interaction ...
Progranulin mutations in clinical and neuropathological Alzheimer’s disease
(Alzheimers Dement., 2022-12-10)
Progranulin (GRN) mutations occur in frontotemporal lobar degeneration
(FTLD) and in Alzheimer’s disease (AD), often with TDP-43 pathology.
We determined the frequency of rs5848 and rare, pathogenic GRN mutations
in two ...
Apolipoprotein E (APOE) genotype, dementia, and memory performance among Caribbean Hispanic versus US populations
(Alzheimer's Association, 2022-06-04)
Apolipoprotein E (APOE) is considered the major susceptibility gene for developing Alzheimer's disease. However, the strength of this risk factor is not well established across diverse Hispanic populations. We investigated ...
Latin American initiative for lifestyle intervention to prevent cognitive decline (LatAm-FINGERS): study design and harmonization
(Alzheimer's Association®, 2023-05-19)
Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS) is the first non-pharmacological multicenter randomized clinical trial (RCT) to prevent cognitive impairment in Latin America ...