• Current status and challenges of stem cell treatment for Alzheimer’s disease 

      Pacheco Herrero, Mar; Soto Rojas, Luis O.; Reyes Sabater, Heidy; Garces Ramírez, Linda; Cruz López, Fidel de la; Villanueva Fierro, Ignacio; Luna Muñoz, José (Journal of Alzheimer’s Disease, 2021)
      Neurodegenerative diseases called tauopathies, such as Alzheimer’s disease (AD), frontotemporal dementia, progressive supranuclear palsy, and Parkinson’s disease, among others, are characterized by the pathological processing ...
    • Elucidating the neuropathologic mechanisms of SARS-cov-2 infection. 

      Pacheco Herrero, Mar; Soto Rojas, Luis O.; Harrington, Charles R.; Flores Martínez, Yazmín M.; Villegas Rojas, Marcos M.; León Aguilar, Alfredo M.; Martínez Gómez, Paola A.; Campa Córdoba, B. Berenice; Apátiga Pérez, Ricardo; Corniel Taveras, Carolin N.; Domínguez García, Jesabelle de J.; Blanco Alvarez, Víctor Manuel; Luna Muñoz, José (Frontiers in Neurology, 2021-04-12)
      The current pandemic caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a public health emergency. To date, March 1, 2021, coronavirus disease 2019 (COVID-19) has caused about 114 ...
    • Human Dental Pulp Stem Cells Display a Potential for Modeling Alzheimer Disease-Related Tau Modifications 

      Karlen, Gazarian; Ramírez García, Luis; Tapía Orozco, Luis; Luna Muñoz, José; Pacheco Herrero, Mar (Frontiers Media S. A., 2021)
      We present here the first description of tau in human dental pulp stem cells (DPSCs) evidenced by RT-PCR data on expression of the gene MAPT and by immunocytochemical detection of epitopes by 12 anti-tau antibodies. The ...
    • Insoluble vascular amyloid deposits trigger disruption of the neurovascular unit in Alzheimer’s disease brains. 

      Soto Rojas, Luis O.; Campa Córdoba, Berenice; Harrington, Charles R.; Salas Casas, Andrés; Hernandes Alejandro, Mario; Villanueva Fierro, Ignacio; Bravo Muñoz, Marely; Garcés Ramírez, Linda; Cruz López, Fidel de la; Ontiveros Torres, Miguel Ángel; Gevorkian, Goar; Pacheco Herrero, Mar; Luna Muñoz, José (Int. J. Mol. Sci, 2021-04-01)
      Alzheimer’s disease (AD) is a neurodegenerative disease, characterized histopathologically by intra-neuronal tau-related lesions and by the accumulation of amyloid -peptide (A ) in the brain parenchyma and around cerebral ...
    • Neurovascular dysfunction and vascular amyloid accumulation as early events in Alzheimer's disease 

      Apatiga Pérez, Ricardo; Soto Rojas, Luis O.; Campa Córdoba, B. Berenice; Luna Viramontes, Nabil Itzi; Cuevas, Elvis; Villanueva‑Fierro, Ignacio; Ontiveros Torres, Miguel Angel; Bravo Múñoz, Marely; Flores Rodríguez, Paola; Garces Ramírez, Linda; Cruz, Fidel de la; Montiel Sosa, José Francisco; Pacheco Herrero, Mar; Luna Muñoz, José (Metabolic Brain Disease, 2021-07)
      Alzheimer's disease (AD) is clinically characterized by a progressive loss of cognitive functions and short-term memory. AD patients present two distinctive neuropathological lesions: neuritic plaques and neurofibrillary ...
    • Tau protein phosphorylated at threonine-231 is expressed abundantly in the cerebellum in prion encephalopathies. 

      Gómez López, Víctor Manuel; Viramontes Pintos, Amparo; Ontiveros Torres, Miguel Ángel; Garcés Ramírez, Linda; Cruz López, Fidel de la; Villanueva Fierro, Ignacio; Bravo Muñoz, Marely; Harrington, Charles R.; Martínez Robles, Sandra; Yescas, Petra; Guadarrama Ortíz, Parménides; Hernándes Alejandro, Mario; Montiel Sosa, Francisco; Pacheco Herrero, Mar; Luna Muñoz, José (Journal of Alzheimer’s Disease, 2021-04-02)
      Transmissible spongiform encephalopathies (TSEs) are rare neurodegenerative disorders that affect animals and humans. Bovine spongiform encephalopathy (BSE) in cattle, and Creutzfeld-Jakob Disease (CJD) in humans belong to ...