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dc.contributor.authorSosa, Ana Luisa
dc.contributor.authorAlbanese, Emiliano
dc.contributor.authorStephan, Blossom C. M
dc.contributor.authorDewey, Michael
dc.contributor.authorAcosta, Daisy
dc.contributor.authorFerri, Cleusa P.
dc.contributor.authorGuerra, Mariella
dc.contributor.authorHuang, Yueqin
dc.contributor.authorJacob, K. S.
dc.contributor.authorJiménez-Velázquez, Ivonne Z.
dc.contributor.authorLlibre Rodríguez, Juan J.
dc.contributor.authorSalas, Aquiles
dc.contributor.authorWilliams, Joseph
dc.contributor.authorAcosta, Isaac
dc.contributor.authorGonzález-Viruet, Maribella
dc.contributor.authorGuerra Hernández, Milagros A
dc.contributor.authorShuran, Li
dc.contributor.authorPrince, Martin J.
dc.contributor.authorStewart, Robert
dc.date.accessioned2020-06-15T14:59:55Z
dc.date.available2020-06-15T14:59:55Z
dc.date.issued2012-02
dc.identifier.citationSosa AL, Albanese E, Stephan BCM, Dewey M, Acosta D, Ferri CP, et al. Prevalence, distribution, and impact of mild cognitive impairment in Latin America, China, and India: a 10/66 population-based study. PLoS Med. [En línea]. 2012 [consultado día mes año]; 9(2): 1-11. Disponible en:en_US
dc.identifier.urihttps://repositorio.unphu.edu.do/handle/123456789/2649
dc.description.abstractRapid demographic ageing is a growing public health issue in many low- and middle-income countries (LAMICs). Mild cognitive impairment (MCI) is a construct frequently used to define groups of people who may be at risk of developing dementia, crucial for targeting preventative interventions. However, little is known about the prevalence or impact of MCI in LAMIC settings. Methods and Findings: Data were analysed from cross-sectional surveys established by the 10/66 Dementia Research Group and carried out in Cuba, Dominican Republic, Peru, Mexico, Venezuela, Puerto Rico, China, and India on 15,376 individuals aged 65+ without dementia. Standardised assessments of mental and physical health, and cognitive function were carried out including informant interviews. An algorithm was developed to define Mayo Clinic amnestic MCI (aMCI). Disability (12-item World Health Organization disability assessment schedule [WHODAS]) and informant-reported neuropsychiatric symptoms (neuropsychiatric inventory [NPI-Q]) were measured. After adjustment, aMCI was associated with disability, anxiety, apathy, and irritability (but not depression); between-country heterogeneity in these associations was only significant for disability. The crude prevalence of aMCI ranged from 0.8% in China to 4.3% in India. Country differences changed little (range 0.6%–4.6%) after standardization for age, gender, and education level. In pooled estimates, aMCI was modestly associated with male gender and fewer assets but was not associated with age or education. There was no significant between-country variation in these demographic associations. Conclusions: An algorithm-derived diagnosis of aMCI showed few sociodemographic associations but was consistently associated with higher disability and neuropsychiatric symptoms in addition to showing substantial variation in prevalence across LAMIC populations. Longitudinal data are needed to confirm findings—in particular, to investigate the predictive validity of aMCI in these settings and risk/protective factors for progression to dementia; however, the large number affected has important implications in these rapidly ageing settings.en_US
dc.language.isoenen_US
dc.publisherPLoS Medicine | www.plosmedicine.orgen_US
dc.relation.ispartofseries;Vol.9
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectDemenciaen_US
dc.subjectInvestigaciónen_US
dc.titlePrevalence, distribution, and impact of mild cognitive impairment in Latin America, China, and India: a 10/66 population-based study.en_US
dc.typeArticleen_US


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