Mostrar el registro sencillo del ítem
Prehospital administration of tranexamic acid in trauma patients: A 1:1 matched comparative study from a level 1 trauma center
dc.contributor.author | El-Menyar, Ayman | |
dc.contributor.author | Sathian, Brijesh | |
dc.contributor.author | Wahlen, Bianca M. | |
dc.contributor.author | Abdelrahman, Husham | |
dc.contributor.author | Peralta, Rubén | |
dc.contributor.author | Al-Thani, Hassan | |
dc.contributor.author | Rizoli, Sandro | |
dc.date.accessioned | 2020-08-09T02:08:21Z | |
dc.date.available | 2020-08-09T02:08:21Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | El-Menyar A, Sathian B, Wahlen BM, Abdelrahman H, Peralta R, Al-Thani H, et al. Prehospital administration of tranexamic acid in trauma patients: A 1:1 matched comparative study from a level 1 trauma center. American Journal of Emergency Medicine [En línea]. 2019 [consultado día mes año]; Disponible en: https://doi.org/10.1016/j.ajem.2019.04.051 | en_US |
dc.identifier.uri | https://repositorio.unphu.edu.do/handle/123456789/2725 | |
dc.description.abstract | The purpose of this study was to test the efficacy of prehospital administration of tranexamic acid (TXA) to injured patients on mortality, thromboembolic events and need for blood transfusion in a level 1 trauma center. Methods: We conducted a retrospective study comparing adult trauma patients receiving or not receiving prehospital TXA between January 2017 and September 2018. Patients not receiving TXA but transfused within 4 h of admission were 1:1 matched to TXA-treated patients for age, sex, injury severity score, head abbreviated injury score, prehospital heart rate and systolic blood pressure. Results: In total 204 patients were included (102 TXA and 102 control), with a mean age of 31 years. On admission, shock index (p = 0.03) and serum lactate (p = 0.001) were greater in the control group, whereas the initial base deficit, hemoglobin levels and EMS time were comparable in both groups. The odd ratio (OR) for shock index ≥0.9 after TXA administration was 0.44 (95% CI 0.23–0.84). The median amount of blood transfusion was greater in the control group [eight units (range 1–40) vs three (range 0–40), p = 0.01] as well as the use of massive blood transfusion [OR 0.35 (95% CI 0.19–0.67)]. In the TXA group, VTE was higher [OR 2.0 (95% CI 0.37–11.40)]; whereas the overall mortality was lower [OR 0.78 (95% CI 0.42–1.45)] without reaching statistical significance. Conclusions: Prehospital TXA administration is associated with less in-hospital blood transfusion and massive transfusion protocol (MTP). There is no significant increase in the thromboembolic events and mortality, however, further evaluation in larger clinical trials is needed. | en_US |
dc.language.iso | en | en_US |
dc.publisher | American Journal of Emergency Medicine | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | Ácido Tranexámico | en_US |
dc.title | Prehospital administration of tranexamic acid in trauma patients: A 1:1 matched comparative study from a level 1 trauma center | en_US |
dc.type | Article | en_US |
Ficheros en el ítem
Ficheros | Tamaño | Formato | Ver |
---|---|---|---|
No hay ficheros asociados a este ítem. |