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dc.contributor.authorAlbanese, Emiliano
dc.contributor.authorTaylor, Clare
dc.contributor.authorSiervo, Mario
dc.contributor.authorStewart, Robert
dc.contributor.authorPrince, Martin J.
dc.contributor.authorAcosta, Daisy
dc.date.accessioned2018-11-23T18:09:11Z
dc.date.available2018-11-23T18:09:11Z
dc.date.issued2013
dc.identifier.citationAlbanese E, Taylor Cl, Siervo M, Stewart R, Prince MJ, Acosta D. Dementia severity and weight loss: a comparison across eight cohorts. the 10/66 study. Alzheimer's & Dementia. 2013 ; 9: 649-656.en
dc.identifier.issn15525260
dc.identifier.urihttps://www.alzheimersanddementia.com/article/S1552-5260(12)02584-8/fulltext
dc.description.abstractWe aimed to investigate the association between dementia severity and weight loss in countries with low and middle incomes, where most prevalent cases reside. Methods: Cross-sectional catchment area surveys were performed in Cuba, Mexico, Venezuela, Peru, Dominican Republic, Puerto Rico, China, and India. In 16,538 older adults (_65 years of age), significant weight loss was self-reported and confirmed by an informant. We conducted neuropsychological testing and clinical and neurological assessments. Dementia severity was determined by applying a validated algorithm and was quantified by the Clinical Dementia Rating Scale. Results: The characteristics of those who reported weight loss varied across countries. In Poisson models, after controlling for relevant covariates and for waist and arm circumferences, dementia severity was associated with reported weight loss (pooled prevalence ratios [95% confidence intervals {CI}] 2.19 [1.98, 2.41]; 3.81 [3.35, 4.33]; and 5.18 [4.41, 6.10] for CDR 0.5, 1, and 2/3, respectively, compared with CDR 0). The association increased linearly through stages of dementia severity in all countries (P for trend , .001), and between-country heterogeneity was minimal. Conclusions: We found a strong gradient effect in the direct association between dementia severity and reported weight loss, homogeneous across sites from eight countries, consistent with mechanistic data on the role of neurodegenerative processes on energy balance and with dietary changes due to disease severity. Considering the well-recognized effect of weight loss on morbidity and mortality and the large number affected by dementia in less resourced countries, amelioration of weight loss in dementia patients should be considered with priority in these settings.en
dc.language.isoenen
dc.publisherAlzheimer's & Dementiaen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDemenciaes_ES
dc.subjectEnfermedad de Alzheimeres_ES
dc.subjectEstadísticas y datos numéricoses_ES
dc.subjectPaíses en desarrolloes_ES
dc.subjectPérdida de pesoes_ES
dc.subjectEnvejecimientoes_ES
dc.subjectAncianoes_ES
dc.titleDementia severity and weight loss: a comparison across eight cohorts. the 10/66 study.en
dc.typeArticleen


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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