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Elucidating the neuropathologic mechanisms of SARS-cov-2 infection.
dc.contributor.author | Pacheco Herrero, Mar | |
dc.contributor.author | Soto Rojas, Luis O. | |
dc.contributor.author | Harrington, Charles R. | |
dc.contributor.author | Flores Martínez, Yazmín M. | |
dc.contributor.author | Villegas Rojas, Marcos M. | |
dc.contributor.author | León Aguilar, Alfredo M. | |
dc.contributor.author | Martínez Gómez, Paola A. | |
dc.contributor.author | Campa Córdoba, B. Berenice | |
dc.contributor.author | Apátiga Pérez, Ricardo | |
dc.contributor.author | Corniel Taveras, Carolin N. | |
dc.contributor.author | Domínguez García, Jesabelle de J. | |
dc.contributor.author | Blanco Alvarez, Víctor Manuel | |
dc.contributor.author | Luna Muñoz, José | |
dc.date.accessioned | 2021-06-11T00:30:04Z | |
dc.date.available | 2021-06-11T00:30:04Z | |
dc.date.issued | 2021-04-12 | |
dc.identifier.citation | Pacheco Herrero M, Soto Rojas LO, Harrington ChR, Flores Martínez YM. Villegas Rojas MM. León Aguilar AM … et al. Elucidating the neuropathologic mechanisms of SARS-cov-2 infection. Frontiers in Neurology. 2021. doi: 10.3389/fneur.2021.660087 | en_US |
dc.identifier.uri | https://repositorio.unphu.edu.do/handle/123456789/3630 | |
dc.description.abstract | The current pandemic caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a public health emergency. To date, March 1, 2021, coronavirus disease 2019 (COVID-19) has caused about 114 million accumulated cases and 2.53 million deaths worldwide. Previous pieces of evidence suggest that SARS-CoV-2 may affect the central nervous system (CNS) and cause neurological symptoms in COVID-19 patients. It is also known that angiotensin-converting enzyme-2 (ACE2), the primary receptor for SARS-CoV-2 infection, is expressed in different brain areas and cell types. Thus, it is hypothesized that infection by this virus could generate or exacerbate neuropathological alterations. However, the molecular mechanisms that link COVID-19 disease and nerve damage are unclear. In this review, we describe the routes of SARS-CoV-2 invasion into the central nervous system. We also analyze the neuropathologic mechanisms underlying this viral infection, and their potential relationship with the neurological manifestations described in patients with COVID-19, and the appearance or exacerbation of some neurodegenerative diseases. | en_US |
dc.language.iso | es | en_US |
dc.publisher | Frontiers in Neurology | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Enfermedades Neurodegenerativas | en_US |
dc.subject | Coronavirus | en_US |
dc.title | Elucidating the neuropathologic mechanisms of SARS-cov-2 infection. | en_US |
dc.type | Article | en_US |