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dc.contributor.authorPacheco Herrero, Mar
dc.contributor.authorSoto Rojas, Luis O.
dc.contributor.authorHarrington, Charles R.
dc.contributor.authorFlores Martínez, Yazmín M.
dc.contributor.authorVillegas Rojas, Marcos M.
dc.contributor.authorLeón Aguilar, Alfredo M.
dc.contributor.authorMartínez Gómez, Paola A.
dc.contributor.authorCampa Córdoba, B. Berenice
dc.contributor.authorApátiga Pérez, Ricardo
dc.contributor.authorCorniel Taveras, Carolin N.
dc.contributor.authorDomínguez García, Jesabelle de J.
dc.contributor.authorBlanco Alvarez, Víctor Manuel
dc.contributor.authorLuna Muñoz, José
dc.date.accessioned2021-06-11T00:30:04Z
dc.date.available2021-06-11T00:30:04Z
dc.date.issued2021-04-12
dc.identifier.citationPacheco Herrero M, Soto Rojas LO, Harrington ChR, Flores Martínez YM. Villegas Rojas MM. León Aguilar AM … et al. Elucidating the neuropathologic mechanisms of SARS-cov-2 infection. Frontiers in Neurology. 2021. doi: 10.3389/fneur.2021.660087en_US
dc.identifier.urihttps://repositorio.unphu.edu.do/handle/123456789/3630
dc.description.abstractThe current pandemic caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a public health emergency. To date, March 1, 2021, coronavirus disease 2019 (COVID-19) has caused about 114 million accumulated cases and 2.53 million deaths worldwide. Previous pieces of evidence suggest that SARS-CoV-2 may affect the central nervous system (CNS) and cause neurological symptoms in COVID-19 patients. It is also known that angiotensin-converting enzyme-2 (ACE2), the primary receptor for SARS-CoV-2 infection, is expressed in different brain areas and cell types. Thus, it is hypothesized that infection by this virus could generate or exacerbate neuropathological alterations. However, the molecular mechanisms that link COVID-19 disease and nerve damage are unclear. In this review, we describe the routes of SARS-CoV-2 invasion into the central nervous system. We also analyze the neuropathologic mechanisms underlying this viral infection, and their potential relationship with the neurological manifestations described in patients with COVID-19, and the appearance or exacerbation of some neurodegenerative diseases.en_US
dc.language.isoesen_US
dc.publisherFrontiers in Neurologyen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectEnfermedades Neurodegenerativasen_US
dc.subjectCoronavirusen_US
dc.titleElucidating the neuropathologic mechanisms of SARS-cov-2 infection.en_US
dc.typeArticleen_US


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional