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Oxidative stress and mitochondrial complex I dysfunction correlate with neurodegeneration in an -synucleinopathy animal model
dc.contributor.author | Morales-Martínez, Adriana | |
dc.contributor.author | Martínez-Gómez, Paola A. | |
dc.contributor.author | Martinez-Fong, Daniel | |
dc.contributor.author | Villegas-Rojas, Marcos M. | |
dc.contributor.author | Pérez-Severiano, Francisca | |
dc.contributor.author | Del Toro-Colín, Miguel A. | |
dc.contributor.author | Delgado-Minjares, Karen M. | |
dc.contributor.author | Blanco-Alvarez, Víctor Manuel | |
dc.contributor.author | Leon-Chavez, Bertha Alicia | |
dc.contributor.author | Aparicio-Trejo, Omar Emiliano | |
dc.contributor.author | Baéz-Cortés, Mauricio T. | |
dc.contributor.author | Cardenas-Aguayo, Maria-del-Carmen | |
dc.contributor.author | Luna-Muñoz, José | |
dc.contributor.author | Pacheco-Herrero, Mar | |
dc.contributor.author | Angeles-López, Quetzalli D. | |
dc.contributor.author | Martínez-Dávila, Irma A. | |
dc.contributor.author | Salinas-Lara, Citlaltepetl | |
dc.contributor.author | Romero-López, José Pablo | |
dc.contributor.author | Sánchez-Garibay, Carlos | |
dc.contributor.author | Méndez-Cruz, Adolfo R. | |
dc.contributor.author | Soto-Rojas, Luis O. | |
dc.date.accessioned | 2023-01-16T15:35:44Z | |
dc.date.available | 2023-01-16T15:35:44Z | |
dc.date.issued | 2022-09-27 | |
dc.identifier.citation | Morales-Martínez A, Martínez-Gómez PA, Martinez-Fong D, Villegas-Rojas MM, Pérez-Severiano F, Del Toro-Colín MA, Delgado-Minjares KM, Blanco-Alvarez VM, Leon-Chavez BA, Aparicio-Trejo OE, Baéz-Cortés MT, Cardenas-Aguayo MD, Luna-Muñoz J, Pacheco-Herrero M, Angeles-López QD, Martínez-Dávila IA, Salinas-Lara C, Romero-López JP, Sánchez-Garibay C, Méndez-Cruz AR, Soto-Rojas LO. Oxidative Stress and Mitochondrial Complex I Dysfunction Correlate with Neurodegeneration in an α-Synucleinopathy Animal Model. Int J Mol Sci. 2022 Sep 27;23(19):11394. Disponible en: doi: 10.3390/ijms231911394. | en_US |
dc.identifier.uri | https://repositorio.unphu.edu.do/handle/123456789/4921 | |
dc.description.abstract | The α-synucleinopathies constitute a subset of neurodegenerative disorders, of which Parkinson's disease (PD) is the most common worldwide, characterized by the accumulation of misfolded α-synuclein in the cytoplasm of neurons, which spreads in a prion-like manner to anatomically interconnected brain areas. However, it is not clear how α-synucleinopathy triggers neurodegeneration. We recently developed a rat model through a single intranigral administration of the neurotoxic β-sitosterol β-D-glucoside (BSSG), which produces α-synucleinopathy. In this model, we aimed to evaluate the temporal pattern of levels in oxidative and nitrosative stress and mitochondrial complex I (CI) dysfunction and how these biochemical parameters are associated with neurodegeneration in different brain areas with α-synucleinopathy (Substantia nigra pars compacta, the striatum, in the hippocampus and the olfactory bulb, where α-syn aggregation spreads). Interestingly, an increase in oxidative stress and mitochondrial CI dysfunction accompanied neurodegeneration in those brain regions. Furthermore, in silico analysis suggests a high-affinity binding site for BSSG with peroxisome proliferator-activated receptors (PPAR) alpha (PPAR-α) and gamma (PPAR-γ). These findings will contribute to elucidating the pathophysiological mechanisms associated with α-synucleinopathies and lead to the identification of new early biomarkers and therapeutic targets. | en_US |
dc.language.iso | en | en_US |
dc.publisher | International Journal o f Molecular Sciences Article | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Enfermedad de Parkinson | en_US |
dc.title | Oxidative stress and mitochondrial complex I dysfunction correlate with neurodegeneration in an -synucleinopathy animal model | en_US |
dc.type | Article | en_US |