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The impact of COVID19 on Mental Health in the Hispanic Caribbean Region 2020
(International Psychogeriatric, 2020)
The recent global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic will leave its shadow over mental health in our society, especially among the most vulnerable such as elderly populations and those ...
The neurovascular unit dysfunction in Alzheimer’s disease
(International Journal o f Molecular Sciences, 2021-02-16)
Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide.
Histopathologically, AD presents with two hallmarks: neurofibrillary tangles (NFTs), and aggregates
of amyloid peptide (A ) both in the ...
Insoluble vascular amyloid deposits trigger disruption of the neurovascular unit in Alzheimer’s disease brains.
(Int. J. Mol. Sci, 2021-04-01)
Alzheimer’s disease (AD) is a neurodegenerative disease, characterized histopathologically
by intra-neuronal tau-related lesions and by the accumulation of amyloid -peptide (A ) in the brain
parenchyma and around cerebral ...
Neurovascular dysfunction and vascular amyloid accumulation as early events in Alzheimer's disease
(Metabolic Brain Disease, 2021-07)
Alzheimer's disease (AD) is clinically characterized by a progressive loss of cognitive functions and short-term memory. AD
patients present two distinctive neuropathological lesions: neuritic plaques and neurofibrillary ...
Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer’s disease
(Acta Neuropathologica, 2024-03)
The risk of developing Alzheimer’s disease (AD) significantly increases in individuals carrying the APOEε4 allele. Elderly
cognitively healthy individuals with APOEε4 also exist, suggesting the presence of cellular ...
The 2022 symposium on dementia and brain aging in low- and middle-income countries: Highlights on research, diagnosis, care, and impact
(Alzheimer’s & Dementia, 2024-02)
Two of every three persons living with dementia reside in low- and middle-income
countries (LMICs). The projected increase in global dementia rates is expected to
affect LMICs disproportionately. However, the majority ...
Evaluation of Plasma Biomarkers for A/T/N Classification of Alzheimer Disease Among Adults of Caribbean Hispanic Ethnicity
(JAMA Netw Open., 2023)
Cerebrospinal fluid (CSF) and plasma biomarkers can detect biological evidence of Alzheimer disease (AD), but their use in low-resource environments and among minority ethnic groups is limited. To assess validated plasma ...
Current status and challenges of stem cell treatment for Alzheimer’s disease
(Journal of Alzheimer’s Disease, 2021)
Neurodegenerative diseases called tauopathies, such as Alzheimer’s disease (AD), frontotemporal dementia, progressive supranuclear palsy, and Parkinson’s disease, among others, are characterized by the pathological processing ...
Prediction of dementia risk in low-income and middleincome countries (the 10/66 Study): an independent external validation of existing models
(Elsevier Ltd., 2020-04)
To date, dementia prediction models have been exclusively developed and tested in high-income countries (HICs). However, most people with dementia live in low-income and middle-income countries (LMICs), where dementia risk ...
FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer’s disease
(Acta Neuropathologica (2022) 144:59–79, 2022-05-24)
Alzheimer’s disease (AD) has been associated with cardiovascular and cerebrovascular risk factors (CVRFs) during middle
age and later and is frequently accompanied by cerebrovascular pathology at death. An interaction ...