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Steroid 5α-reductase deficiency in man: An inherited form of male pseudohermaphroditism
(Science, 1974-12-27)In male pseudohermaphrodites born with ambiguity of the external genitalia but with marked virilization at puberty, biochemical evaluation reveals a marked decrease in plasma dihydrotestosterone secondary to a decrease in ... -
Gender identity and hermaphroditism
(Science, 1976) -
Male pseudohermaphroditism due to steroid 5-alpha-reductase deficiency
(PublMed, 1977)A new inherited form of male pseudohermaphroditism has been investigated in a pedigree of 24 families with 38 affected males. At birth, the affected males (46 XY) have a clitoral-like phallus, bifid scrotum and urogenital ... -
Estimadores formales de Bayes en el modelo aleatorio general de clasificación doble cruzado
(Springer Link, 1978)Se desarrollaron algunos estimadores formales de Bayes de los componentes de varianza en el modelo de clasificación doble cruzado de efectos aleatorios con una observación por celda. La generalización de tales estimadores ... -
Male pseudohermaphroditism secondary to 5α-reductase deficiency—A model for the role of androgens in both the development of the male phenotype and the evolution of a male gender identity
(Journal of Steroid Biochemistry, 1979)Male pseudohermaphroditism secondary to 5α-reductase deficiency is reviewed. At birth, the affected males (46 XY) have a clitoral-like phallus, bifid scrotum and urogenital sinus with the testes in the inguinal canals or ... -
Androgens and the evolution of male-gender identity among male pseudohermaphrodites with 5α-reductase deficiency
(N Engl J Med, 1979)To determine the contribution of androgens to the formation of male-gender identity, we studied male pseudohermaphrodites who had decreased dihydrotestosterone production due to 5α-reductase deficiency. These subjects were ... -
Androgens and the evolution of male-gender identity among male pseudohermaphrodites with 5alpha-reductase deficiency.
(New England Journal of Medicine, 1979-05-19)To determine the contribution of androgens to the formation of male-gender identity, we studied male pseudohermaphrodites who had decreased dihydrotestosterone production due to 5 alpha-reductase deficiency. These subjects ... -
A histochemical and ultrastructural study of human breast carcinomas with a view to their classification by cell of origin
(Experimental and Molecular Pathology, 1979-08)We have studied 450 cases of human breast carcinoma at the histochemical and ultrastructural level. The breast biopsies were obtained from Canada, Mexico and Dominican Republic.This study was undertaken to evaluate the ... -
Potentially dangerous effect of disopyramide on atrioventricular conduction in a patient on digitalis
(British Medical Journal, 1980) -
Testicular function in 2 cases of penile agenesis
(The Journal of Urology, 1981-10-05)Two cases of congenital absence of the penis are presented. In both cases testicular androgen function was adequate, as judged by measurements of plasma androgens after administration of human chorionic gonadotropin -
Hormonal evaluation of a large kindred with complete androgen insensitivity: evidence for secondary 5α-reductase deficiency.
(The Journal of Clinical Endocrinology & Metabolism, 1982-05)Seventeen individuals from a pedigree with complete androgen insensitivity, [testicular feminization (TF)] are presented. Their hormonal evaluation was compared with those of normal males and male pseudohermaphrodites with ... -
Decreased Urinary C19 and C21 Steroid 5α-Metabolites in Parents of Male Pseudohermaphrodites with 5α- Reductase Deficiency: Detection of Carriers
(The Journal of Clinical Endocrinology & Metabolism, 1985-05-01)The urinary 5β/5α ring A-reduced metabolites of C19 and C12 steroids from obligate carrier parents of male) pseudohermaphrodites with 5a-reductase deficiency were analyzed by gas chromatography. Etiocholanolone/androsterone, ... -
Urinary steroid metabolites in subjects with male pseudohermaphroditism due to 5α-reductase deficiency
(Wiley, 1985-07)To investigate the enzymatic basis for abnormal steroid metabolism in subjects with male pseudohermaphroditism due to 5α-reductase deficiency, the ring A reduced urinary 5β and 5α metabolites of testosterone, androstenedione, ... -
Male pseudohermaphroditism due to multiple defects in steroid-biosynthetic microsomal mixed-function oxidases — a new variant of congenital adrenal hyperplasia
(New England Journal of Medicine, 1985-11-07)A six-month-old 46,XY infant with a female phenotype and ambiguous genitalia was evaluated for male pseudohermaphroditism. The principal findings were (1) low basal plasma levels of all measured C19 steroids and their ... -
Inherited 5α-reductase deficiency in man
(ScienceDirect, 1986)Study of the syndrome of 5α-reductase deficiency in man has elucidated the importance of testosterone conversion to dihydrotestosterone in sexual differentiation of the male fetus. Insights into specific actions for ... -
The diagnosis of 5α-reductase deficiency in infancy
(Journal of Clinical Endocrinology and Metabolism, 1986-12)The diagnosis of 5α-reductase deficiency in infancy is reported for the first timein three male pseudohermaphrodites from the Dominican Republic. Basal plasma testosterone to dihydrotestosterone ratios were significantly ... -
Prevalence of antibodies to the human immunodeficiency virus in dominicans and haitians in the Dominican Republic.
(JAMA, 1987)Few patients with the acquired immunodeficiency syndrome have been reported in the Dominican Republic, although they share the island of Hispaniola with Haiti, which has numerous cases. Prevalence of antibodies to the human ... -
Reversibility of catecholamine-induced dilated cardiomyopathy in a child with a pheochromocytoma
(N Engl J Med, 1987-03-26)Patients with a severe, dilated cardiomyopathy with congestive heart failure have a poor prognosis unless a correctable cause can be identified. Even when a cause is found, the degree of reversibility of myocardial injury ... -
Determination of thin surface layers in-situ by the conversion electron mössbauer spectroscopy /CEMS/, using a parallel plate avalanche counter /PPAC/
(Journal of Radioanalytical and Nuclear Chemistry, 1988)In the present paper we describe a technique for the determination of thin layer thicknesses by the conversion electron Mössbauer spectroscopy /CEMS/, using a new alternative method, a parallel plate avalanche counter ... -
A low-cost LN2 monitor
(American Journal of Physician, 1989)