ListarArtículos por tema "Enfermedad de Alzheimer"
Mostrando ítems 1-19 de 19
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Ageing and dementia in low and middle income countries - Using research to engage with public and policy makers.
(In ternational Review of Psychiatry, 2008)While two thirds of the 24 million people with dementia worldwide live in low and middle income countries, very little research has been conducted to support policy making in these regions. Among the non-communicable ... -
Alzheimer’s disease: an updated overview of its genetics
(International Journal o f Molecular Sciences, 2023-02-13)Alzheimer’s disease (AD) is the most common neurodegenerative disease in the world. It is classified as familial and sporadic. The dominant familial or autosomal presentation represents 1–5% of the total number of cases. ... -
Apolipoprotein E (APOE) genotype, dementia, and memory performance among Caribbean Hispanic versus US populations
(Alzheimer's Association, 2022-06-04)Apolipoprotein E (APOE) is considered the major susceptibility gene for developing Alzheimer's disease. However, the strength of this risk factor is not well established across diverse Hispanic populations. We investigated ... -
Current status and challenges of stem cell treatment for Alzheimer’s disease
(Journal of Alzheimer’s Disease, 2021)Neurodegenerative diseases called tauopathies, such as Alzheimer’s disease (AD), frontotemporal dementia, progressive supranuclear palsy, and Parkinson’s disease, among others, are characterized by the pathological processing ... -
Dementia attributable healthcare utilizations in the Caribbean versus United States
(Journal of Alzheimer's Disease, 2023-11-07)Despite the high burden of Alzheimer's disease and other dementias among the Hispanic population worldwide, little is known about how dementia affects healthcare utilizations among this population outside of the US, in ... -
Dementia diagnosis in developing countries: a cross-cultural validation study.
(Elsevier Limited, 2003)Research into dementia is needed in developing countries. Assessment of variations in disease frequency between regions might enhance our understanding of the disease, but methodological difficulties need to be addressed. ... -
Dementia severity and weight loss: a comparison across eight cohorts. the 10/66 study.
(Alzheimer's & Dementia, 2013)We aimed to investigate the association between dementia severity and weight loss in countries with low and middle incomes, where most prevalent cases reside. Methods: Cross-sectional catchment area surveys were performed ... -
Evaluation of Plasma Biomarkers for A/T/N Classification of Alzheimer Disease Among Adults of Caribbean Hispanic Ethnicity
(JAMA Netw Open., 2023)Cerebrospinal fluid (CSF) and plasma biomarkers can detect biological evidence of Alzheimer disease (AD), but their use in low-resource environments and among minority ethnic groups is limited. To assess validated plasma ... -
FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer’s disease
(Acta Neuropathologica (2022) 144:59–79, 2022-05-24)Alzheimer’s disease (AD) has been associated with cardiovascular and cerebrovascular risk factors (CVRFs) during middle age and later and is frequently accompanied by cerebrovascular pathology at death. An interaction ... -
The impact of COVID19 on Mental Health in the Hispanic Caribbean Region 2020
(International Psychogeriatric, 2020)The recent global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic will leave its shadow over mental health in our society, especially among the most vulnerable such as elderly populations and those ... -
Insoluble vascular amyloid deposits trigger disruption of the neurovascular unit in Alzheimer’s disease brains.
(Int. J. Mol. Sci, 2021-04-01)Alzheimer’s disease (AD) is a neurodegenerative disease, characterized histopathologically by intra-neuronal tau-related lesions and by the accumulation of amyloid -peptide (A ) in the brain parenchyma and around cerebral ... -
Interpretable Classification of Tauopathies with a Convolutional Neural Network Pipeline Using Transfer Learning and Validation against Post-Mortem Clinical Cases of Alzheimer’s Disease and Progressive Supranuclear Palsy
(MDP, 2022-11-22)Neurodegenerative diseases, tauopathies, constitute a serious global health problem. The etiology of these diseases is unclear and an increase in their incidence has been projected in the next 30 years. Therefore, the ... -
Latin American initiative for lifestyle intervention to prevent cognitive decline (LatAm-FINGERS): study design and harmonization
(Alzheimer's Association®, 2023-05-19)Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS) is the first non-pharmacological multicenter randomized clinical trial (RCT) to prevent cognitive impairment in Latin America ... -
Neurovascular dysfunction and vascular amyloid accumulation as early events in Alzheimer's disease
(Metabolic Brain Disease, 2021-07)Alzheimer's disease (AD) is clinically characterized by a progressive loss of cognitive functions and short-term memory. AD patients present two distinctive neuropathological lesions: neuritic plaques and neurofibrillary ... -
The neurovascular unit dysfunction in Alzheimer’s disease
(International Journal o f Molecular Sciences, 2021-02-16)Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide. Histopathologically, AD presents with two hallmarks: neurofibrillary tangles (NFTs), and aggregates of amyloid peptide (A ) both in the ... -
Packages of care for dementia in low- and middle-income countries.
(PolS Medicine, 2009)This is the fifth in a series of articles highlighting the delivery of "packages of care" for mental health disorders in low- and middle-income countries. Packages of care are combinations of treatments aimed at improving ... -
Population normative data for the 10/66 Dementia Research Group cognitive test battery from Latin America, India and China: a cross-sectional survey.
(BMC Neurology, 2009)1) To report site-specific normative values by age, sex and educational level for four components of the 10/66 Dementia Research Group cognitive test battery; 2) to estimate the main and interactive effects of age, sex, ... -
Prediction of dementia risk in low-income and middleincome countries (the 10/66 Study): an independent external validation of existing models
(Elsevier Ltd., 2020-04)To date, dementia prediction models have been exclusively developed and tested in high-income countries (HICs). However, most people with dementia live in low-income and middle-income countries (LMICs), where dementia risk ... -
Progranulin mutations in clinical and neuropathological Alzheimer’s disease
(Alzheimers Dement., 2022-12-10)Progranulin (GRN) mutations occur in frontotemporal lobar degeneration (FTLD) and in Alzheimer’s disease (AD), often with TDP-43 pathology. We determined the frequency of rs5848 and rare, pathogenic GRN mutations in two ...
