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Dementia Research in the Caribbean Hispanic Islands: Present Findings and Future Trends
(Front. Public Health, 2021-01-18)
During the last decade, the Caribbean Hispanic islands experienced accelerated demographic aging, representing the fastest aging region within Latin America. Age-related non-communicable diseases, including dementia, are ...
Prevalence, distribution, and impact of mild cognitive impairment in Latin America, China, and India: a 10/66 population-based study.
(PLoS Medicine | www.plosmedicine.org, 2012-02)
Rapid demographic ageing is a growing public health issue in many low- and middle-income countries
(LAMICs). Mild cognitive impairment (MCI) is a construct frequently used to define groups of people who may be at risk ...
Progranulin mutations in clinical and neuropathological Alzheimer’s disease
(Alzheimers Dement., 2022-12-10)
Progranulin (GRN) mutations occur in frontotemporal lobar degeneration
(FTLD) and in Alzheimer’s disease (AD), often with TDP-43 pathology.
We determined the frequency of rs5848 and rare, pathogenic GRN mutations
in two ...
Apolipoprotein E (APOE) genotype, dementia, and memory performance among Caribbean Hispanic versus US populations
(Alzheimer's Association, 2022-06-04)
Apolipoprotein E (APOE) is considered the major susceptibility gene for developing Alzheimer's disease. However, the strength of this risk factor is not well established across diverse Hispanic populations. We investigated ...
Latin American initiative for lifestyle intervention to prevent cognitive decline (LatAm-FINGERS): study design and harmonization
(Alzheimer's Association®, 2023-05-19)
Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS) is the first non-pharmacological multicenter randomized clinical trial (RCT) to prevent cognitive impairment in Latin America ...