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Long-term growth hormone therapy in adulthood results in significant linear growth in siblings with a PROP-1 gene mutation.
(Journal of Clinical Endocrinology and Metabolism, 2004)
PROP-1 g ene mutations result in impaired production of GH, gonadotropins, TSH, and prolactin. We describe three adult
siblings, aged 18-25 yr, with short stature, hypothyroidism, and lack of pubertal maturation, who were ...