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Oxidative stress and mitochondrial complex I dysfunction correlate with neurodegeneration in an -synucleinopathy animal model
(International Journal o f Molecular Sciences Article, 2022-09-27)
The α-synucleinopathies constitute a subset of neurodegenerative disorders, of which Parkinson's disease (PD) is the most common worldwide, characterized by the accumulation of misfolded α-synuclein in the cytoplasm of ...
Autophagy: A key regulator of homeostasis and disease: an overview of molecular mechanisms and modulators
(Cells., 2022-08-22)
Autophagy is a highly conserved lysosomal degradation pathway active at basal levels
in all cells. However, under stress conditions, such as a lack of nutrients or trophic factors, it
works as a survival mechanism that ...
Biomarker Candidates for Alzheimer’s Disease Unraveled through In Silico Differential Gene Expression Analysis
(Basel, 2022-05-07)
Alzheimer’s disease (AD) is neurodegeneration that accounts for 60–70% of dementia cases.
Symptoms begin with mild memory difficulties and evolve towards cognitive impairment. The
underlying risk factors remain primarily ...
Autophagy: A Key Regulator of Homeostasis and Disease: An Overview of Molecular Mechanisms and Modulators
(Cells, 2022)
Autophagy is a highly conserved lysosomal degradation pathway active at basal levels
in all cells. However, under stress conditions, such as a lack of nutrients or trophic factors, it
works as a survival mechanism that ...