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Human Dental Pulp Stem Cells Display a Potential for Modeling Alzheimer Disease-Related Tau Modifications

Karlen, Gazarian; Ramírez García, Luis; Tapía Orozco, Luis; Luna Muñoz, José; Pacheco Herrero, Mar (Frontiers Media S. A., 2021)

We present here the first description of tau in human dental pulp stem cells (DPSCs) evidenced by RT-PCR data on expression of the gene MAPT and by immunocytochemical detection of epitopes by 12 anti-tau antibodies. The ...

Tau protein phosphorylated at threonine-231 is expressed abundantly in the cerebellum in prion encephalopathies.

Gómez López, Víctor Manuel; Viramontes Pintos, Amparo; Ontiveros Torres, Miguel Ángel; Garcés Ramírez, Linda; Cruz López, Fidel de la; Villanueva Fierro, Ignacio; Bravo Muñoz, Marely; Harrington, Charles R.; Martínez Robles, Sandra; Yescas, Petra; Guadarrama Ortíz, Parménides; Hernándes Alejandro, Mario; Montiel Sosa, Francisco; Pacheco Herrero, Mar; Luna Muñoz, José (Journal of Alzheimer’s Disease, 2021-04-02)

Transmissible spongiform encephalopathies (TSEs) are rare neurodegenerative disorders that affect animals and humans. Bovine spongiform encephalopathy (BSE) in cattle, and Creutzfeld-Jakob Disease (CJD) in humans belong to ...

Insoluble vascular amyloid deposits trigger disruption of the neurovascular unit in Alzheimer’s disease brains.

Soto Rojas, Luis O.; Campa Córdoba, Berenice; Harrington, Charles R.; Salas Casas, Andrés; Hernandes Alejandro, Mario; Villanueva Fierro, Ignacio; Bravo Muñoz, Marely; Garcés Ramírez, Linda; Cruz López, Fidel de la; Ontiveros Torres, Miguel Ángel; Gevorkian, Goar; Pacheco Herrero, Mar; Luna Muñoz, José (Int. J. Mol. Sci, 2021-04-01)

Alzheimer’s disease (AD) is a neurodegenerative disease, characterized histopathologically by intra-neuronal tau-related lesions and by the accumulation of amyloid -peptide (A ) in the brain parenchyma and around cerebral ...

Elucidating the neuropathologic mechanisms of SARS-cov-2 infection.

Pacheco Herrero, Mar; Soto Rojas, Luis O.; Harrington, Charles R.; Flores Martínez, Yazmín M.; Villegas Rojas, Marcos M.; León Aguilar, Alfredo M.; Martínez Gómez, Paola A.; Campa Córdoba, B. Berenice; Apátiga Pérez, Ricardo; Corniel Taveras, Carolin N.; Domínguez García, Jesabelle de J.; Blanco Alvarez, Víctor Manuel; Luna Muñoz, José (Frontiers in Neurology, 2021-04-12)

The current pandemic caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a public health emergency. To date, March 1, 2021, coronavirus disease 2019 (COVID-19) has caused about 114 ...

Neurovascular dysfunction and vascular amyloid accumulation as early events in Alzheimer's disease

Apatiga Pérez, Ricardo; Soto Rojas, Luis O.; Campa Córdoba, B. Berenice; Luna Viramontes, Nabil Itzi; Cuevas, Elvis; Villanueva‑Fierro, Ignacio; Ontiveros Torres, Miguel Angel; Bravo Múñoz, Marely; Flores Rodríguez, Paola; Garces Ramírez, Linda; Cruz, Fidel de la; Montiel Sosa, José Francisco; Pacheco Herrero, Mar; Luna Muñoz, José (Metabolic Brain Disease, 2021-07)

Alzheimer's disease (AD) is clinically characterized by a progressive loss of cognitive functions and short-term memory. AD patients present two distinctive neuropathological lesions: neuritic plaques and neurofibrillary ...