Now showing items 1-5 of 5
Human Dental Pulp Stem Cells Display a Potential for Modeling Alzheimer Disease-Related Tau Modifications
(Frontiers Media S. A., 2021)
We present here the first description of tau in human dental pulp stem cells (DPSCs) evidenced by RT-PCR data on expression of the gene MAPT and by immunocytochemical detection of epitopes by 12 anti-tau antibodies. The ...
Tau protein phosphorylated at threonine-231 is expressed abundantly in the cerebellum in prion encephalopathies.
(Journal of Alzheimer’s Disease, 2021-04-02)
Transmissible spongiform encephalopathies (TSEs) are rare neurodegenerative disorders that affect animals and humans. Bovine spongiform encephalopathy (BSE) in cattle, and Creutzfeld-Jakob Disease (CJD) in humans belong to ...
Insoluble vascular amyloid deposits trigger disruption of the neurovascular unit in Alzheimer’s disease brains.
(Int. J. Mol. Sci, 2021-04-01)
Alzheimer’s disease (AD) is a neurodegenerative disease, characterized histopathologically by intra-neuronal tau-related lesions and by the accumulation of amyloid -peptide (A ) in the brain parenchyma and around cerebral ...
Elucidating the neuropathologic mechanisms of SARS-cov-2 infection.
(Frontiers in Neurology, 2021-04-12)
The current pandemic caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a public health emergency. To date, March 1, 2021, coronavirus disease 2019 (COVID-19) has caused about 114 ...
Neurovascular dysfunction and vascular amyloid accumulation as early events in Alzheimer's disease
(Metabolic Brain Disease, 2021-07)
Alzheimer's disease (AD) is clinically characterized by a progressive loss of cognitive functions and short-term memory. AD patients present two distinctive neuropathological lesions: neuritic plaques and neurofibrillary ...