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Oxidative stress and mitochondrial complex I dysfunction correlate with neurodegeneration in an -synucleinopathy animal model
(International Journal o f Molecular Sciences Article, 2022-09-27)
The α-synucleinopathies constitute a subset of neurodegenerative disorders, of which Parkinson's disease (PD) is the most common worldwide, characterized by the accumulation of misfolded α-synuclein in the cytoplasm of ...
Prevalence of parkinsonism and Parkinson disease in urban and rural populations from Latin America: A community based study
(The Lancet Regional Health - Americas 2022;7: 100136, 2021-12-10)
Age and gender specific prevalence rates for parkinsonism and Parkinson’s disease (PD) are important
to guide research, clinical practice, and public health planning; however, prevalence estimates in Latin America
(LatAm) ...
Mechanistic Insight from Preclinical Models of Parkinson’s Disease Could Help Redirect Clinical Trial Efforts in GDNF Therapy
(Int. J. Mol. Sci, 2021)
Parkinson’s disease (PD) is characterized by four pathognomonic hallmarks: (1) motor
and non-motor deficits; (2) neuroinflammation and oxidative stress; (3) pathological aggregates of
the α-synuclein (α-syn) protein; (4) ...