The 10/66 Dementia Research Group's fully operationalised DSM-IV dementia computerized diagnostic algorithm, compared with the 10/66 dementia algorithm and a clinician diagnosis: a population validation study
Fecha
2007-07-20Autor
Prince, Martin J.
Ferri, Cleusa P.
Acosta, Daisy
Albanese, Emiliano
Arizaga, Raúl
Dewey, Michael
Gavrilova, Svetlana I.
Guerra, Mariella
Huang, Yueqin
Jacob, KS
Krishnamoorthy, ES
McKeigue, Paul
Llibre Rodriguez, Juan
Salas, Aquiles
Sosa, Ana Luisa
Sousa, Renata MM
Stewart, Robert
Uwakwe, Richard
Metadatos
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Latin America, China and India are experiencing unprecedentedly rapid demographic ageing with an
increasing number of people with dementia. The 10/66 Dementia Research Group's title refers to the 66% of people with
dementia that live in developing countries and the less than one tenth of population-based research carried out in those
settings. This paper describes the protocols for the 10/66 population-based and intervention studies that aim to redress
this imbalance.
Methods/design: Cross-sectional comprehensive one phase surveys have been conducted of all residents aged 65 and
over of geographically defined catchment areas in ten low and middle income countries (India, China, Nigeria, Cuba,
Dominican Republic, Brazil, Venezuela, Mexico, Peru and Argentina), with a sample size of between 1000 and 3000
(generally 2000). Each of the studies uses the same core minimum data set with cross-culturally validated assessments
(dementia diagnosis and subtypes, mental disorders, physical health, anthropometry, demographics, extensive non
communicable disease risk factor questionnaires, disability/functioning, health service utilisation, care arrangements and
caregiver strain). Nested within the population based studies is a randomised controlled trial of a caregiver intervention
for people with dementia and their families (ISRCTN41039907; ISRCTN41062011; ISRCTN95135433; ISRCTN66355402; ISRCTN93378627; ISRCTN94921815). A follow up of 2.5 to 3.5 years will be conducted in 7
countries (China, Cuba, Dominican Republic, Venezuela, Mexico, Peru and Argentina) to assess risk factors for incident
dementia, stroke and all cause and cause-specific mortality; verbal autopsy will be used to identify causes of death.
Discussion: The 10/66 DRG baseline population-based studies are nearly complete. The incidence phase will be
completed in 2009. All investigators are committed to establish an anonymised file sharing archive with monitored public
access. Our aim is to create an evidence base to empower advocacy, raise awareness about dementia, and ensure that
the health and social care needs of older people are anticipated and met.
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