Using Regional Sero-Epidemiology SARS-CoV-2 Anti-S Antibodies in the Dominican Republic to Inform Targeted Public Health Response
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Date
2023-11Author
Mario Martin, Beatris
Cadavid Restrepo, Angela
Mayfield, Helen J.
Then Paulino, Cecilia
De St Aubin, Micheal
Duke, William
Jarolim, Petr
Zielinski Gutiérrez, Emily
Skewes Ramm, Ronald
Dumas, Devan
Garnier, Salome
Etienne, Marie Caroline
Peña, Farah
Abdalla, Gabriela
Lopez, Beatriz
Cruz, Lucia de la
Henríquez, Bernarda
Baldwin, Margaret
Sartorius, Benn
Kucharski, Adam
James Nilles, Eric
Colleen, Lau
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Show full item recordAbstract
Incidence of COVID-19 has been associated with sociodemographic factors. We investigated
variations in SARS-CoV-2 seroprevalence at sub-national levels in the Dominican Republic and
assessed potential factors influencing variation in regional-level seroprevalence. Data were collected
in a three-stage cross-sectional national serosurvey from June to October 2021. Seroprevalence of
antibodies against the SARS-CoV-2 spike protein (anti-S) was estimated and adjusted for selection
probability, age, and sex. Multilevel logistic regression was used to estimate the effect of covariates
on seropositivity for anti-S and correlates of 80% protection (PT80) against symptomatic infection for
the ancestral and Delta strains. A total of 6683 participants from 134 clusters in all 10 regions were
enrolled. Anti-S, PT80 for the ancestral and Delta strains odds ratio varied across regions, Enriquillo
presented significant higher odds for all outcomes compared with Yuma. Compared to being
unvaccinated, receiving 2 doses of COVID-19 vaccine was associated with a significantly higher
odds of anti-S positivity (OR 85.94, [10.95–674.33]) and PT80 for the ancestral (OR 4.78, [2.15–10.62])
and Delta strains (OR 3.08, [1.57–9.65]) nationally and also for each region. Our results can help
inform regional-level public health response, such as strategies to increase vaccination coverage in
areas with low population immunity against currently circulating strains.
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