Learnings from real-life experience of using omalizumab for chronicurticaria in Latin America
Fecha
2019-01-08Autor
Cherrez Ojeda, Iván
Maurer, Marcus
Bernstein, Jonathan A
Vanegas, Emanuel
Félix, Miguel
Ramón, Germán D.
Ensina, Luis Felipe
Larco Sousa, José Ignacio
Matos Benavides, Edgar Emilio
Cardona Villa, R.
Latour Staffeld, P.
Morfin-Maciel, Blanca María
Mori, José
Wilches C, Paul
Mata, Valeria L.
Cherrez, Annia
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Updated urticaria guidelines recommend that patients should be assessed for disease activity, severity,
control, and quality of life at baseline and follow up. Regarding treatment, guidelines consider second generation antihistamines as the cornerstone in therapy for chronic urticaria (CU), while other drugs, such as omalizumab, are conceived as second-line alternatives. In regards to omalizumab, despite advances in the management of CU, there are still open questions about timing, dosing, and objective measures for clinical response. This study was designed to portray the use of patient-reported outcomes (PROs) in chronic urticaria management, as well as the effectiveness and treatment patterns of omalizumab in CU, as seen in a real-life setting in Latin America.
Methods: This is a retrospective observational study, involving 72 Latin American patients with chronic urticaria
treated with omalizumab. Patient reported outcomes and treatment patterns, response, quality of life improvement and discontinuation were analyzed.
Results: From the 72 patients, 91.7% (n ¼ 66) were assessed through PROs, where urticaria control test (UCT) was
the most used (79.2%; n ¼ 57). Overall, 80.0% (n ¼ 44) responded to omalizumab at some point of the treatment.
Omalizumab 300 mg was associated with earlier response compared to lower doses. Regardless of dosage, most
patients assessed with CU-Q2oL improved quality of life (80.8%; n ¼ 21). With respect to omalizumab discontinuation, 20.8% (n ¼ 15) patients interrupted omalizumab before the 3rd month of treatment (p ¼ .000).
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