Buscar
Mostrando ítems 1-10 de 35
Oxidative stress and mitochondrial complex I dysfunction correlate with neurodegeneration in an -synucleinopathy animal model
(International Journal o f Molecular Sciences Article, 2022-09-27)
The α-synucleinopathies constitute a subset of neurodegenerative disorders, of which Parkinson's disease (PD) is the most common worldwide, characterized by the accumulation of misfolded α-synuclein in the cytoplasm of ...
Morphological and fractal properties of brain tumors
(Frontiers in Physiology, 2022-06-27)
Tumor interface dynamics is a complex process determined by cell proliferation and
invasion to neighboring tissues. Parameters extracted from the tumor interface fluctuations
allow for the characterization of the particular ...
Biomarkers for dementia in Latin American countries: Gaps and opportunities
(Alzheimer’s & Dementia, 2022-01-15)
Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC)
countries remains a serious barrier. Here, we reported a survey to explore the ongoing
work, needs, interests, potential barriers, and ...
SARS-CoV-2 seroprevalence, cumulative infections, and immunity to symptomatic infection – A multistage national household survey and modelling study, Dominican Republic, June–October 2021
(Elsevier Ltd., 2022-11-08)
Background Population-level SARS-CoV-2 immunological protection is poorly understood but can guide vaccination and non-pharmaceutical intervention priorities. Our objective was to characterise cumulative infections and ...
Consumo de alcohol y otras sustancias psicoactivas en adolescentes dominicanos
(Revista Iberoamericana de Diagnóstico y Evaluación, 2022-05-02)
El consumo de sustancias psicoactivas en adolescentes representa un problema de salud pública, pero República Dominicana no monitorea su evolución. Información sobre patrones de consumo, edad de inicio, contextos de riesgo ...
Autophagy: A key regulator of homeostasis and disease: an overview of molecular mechanisms and modulators
(Cells., 2022-08-22)
Autophagy is a highly conserved lysosomal degradation pathway active at basal levels
in all cells. However, under stress conditions, such as a lack of nutrients or trophic factors, it
works as a survival mechanism that ...
Biomarker Candidates for Alzheimer’s Disease Unraveled through In Silico Differential Gene Expression Analysis
(Basel, 2022-05-07)
Alzheimer’s disease (AD) is neurodegeneration that accounts for 60–70% of dementia cases.
Symptoms begin with mild memory difficulties and evolve towards cognitive impairment. The
underlying risk factors remain primarily ...
A Novel Automatic Quantification Protocol for Biomarkers of Tauopathies in the Hippocampus and Entorhinal Cortex of Post-Mortem Samples Using an Extended Semi-Siamese U-Net
(Biology., 2022-07-28)
Efforts have been made to diagnose and predict the course of different neurodegenerative
diseases through various imaging techniques. Particularly tauopathies, where the tau polypeptide
is a key participant in molecular ...
What trauma patients need: the European dilemma
(European Journal of Trauma and Emergency Surgery, 2022-07-22)
There is a need for implementation and maturation of an inclusive trauma system in every country in Europe, with patient centered care by dedicated surgeons. This process should be initiated by physicians and medical ...
Characterization of lime mortar and plasters of Fortress Concepción de la Vega
(MatTech, 2022-06-10)
The arrival of Christopher Columbus in America stimulated the creation of new settlements in which the materials and construction
methods coming from Spain and those existing in the area were used. The first village built ...