Morphological and fractal properties of brain tumors
Fecha
2022-06-27Autor
Sánchez, Jacksson
Martín-Landrove, Miguel
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Tumor interface dynamics is a complex process determined by cell proliferation and
invasion to neighboring tissues. Parameters extracted from the tumor interface fluctuations
allow for the characterization of the particular growth model, which could be relevant for an
appropriate diagnosis and the correspondent therapeutic strategy. Previous work, based
on scaling analysis of the tumor interface, demonstrated that gliomas strictly behave as it is
proposed by the Family-Vicsek ansatz, which corresponds to a proliferative-invasive
growth model, while for meningiomas and acoustic schwannomas, a proliferative
growth model is more suitable. In the present work, other morphological and
dynamical descriptors are used as a complementary view, such as surface regularity,
one-dimensional fluctuations represented as ordered series and bi-dimensional
fluctuations of the tumor interface. These fluctuations were analyzed by Detrended
Fluctuation Analysis to determine generalized fractal dimensions. Results indicate that
tumor interface fractal dimension, local roughness exponent and surface regularity are
parameters that discriminate between gliomas and meningiomas/schwannomas.
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