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The impact of SARS-CoV-2 in dementia across Latin America: A call for an urgent regional plan and coordinated response
(Translational Research & Clinical Interventions, 2020)
The SARS-CoV-2 global pandemic will disproportionately impact countries with weak economies and vulnerable populations including people with dementia. Latin American and Caribbean countries (LACs) are burdened with unstable ...
Prediction of dementia risk in low-income and middleincome countries (the 10/66 Study): an independent external validation of existing models
(Elsevier Ltd., 2020-04)
To date, dementia prediction models have been exclusively developed and tested in high-income countries (HICs). However, most people with dementia live in low-income and middle-income countries (LMICs), where dementia risk ...
The prevalence and correlates of frailty in urban and rural populations in Latin America, China, and India: A 10/66 population-based survey
(Elsevier Ltd., 2018)
There have been few cross-national studies of the prevalence of the frailty phenotype conducted among low or middle income countries. We aimed to study the variation in prevalence and correlates of frailty in rural and ...
Dementia attributable healthcare utilizations in the Caribbean versus United States
(Journal of Alzheimer's Disease, 2023-11-07)
Despite the high burden of Alzheimer's disease and other dementias among the Hispanic population worldwide, little is known about how dementia affects healthcare utilizations among this population outside of the US, in ...
Care arrangements for people with dementia in developing countries
(International Journal of Geriatric Psychiatry, 2004-01-28)
Rapid demographic ageing will soon lead to large increases in the numbers of persons with dementia in developing countries. This study is the first comprehensive assessment of care arrangements for people with dementia in ...
Chronic diseases among older people and co-resident psychological morbidity: A 10/66 Dementia Research Group population-based survey
(Int Psychogeriatr ., 2011-11)
This is the first study to investigate the associations between chronic health conditions of older people and their impact on co-resident psychological morbidity using population-based samples in low and middle income ...
Tobacco use and dementia: evidence from the 1066 dementia population-based surveys in Latin America, China and India
(International Journal of Geriatric Psychiatry, 2011-02-09)
To assess the association between tobacco consumption and dementia using the same methodology in seven developing countries, testing the specific hypotheses that higher exposure to tobacco is associated with a higher ...
FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer’s disease
(Acta Neuropathologica (2022) 144:59–79, 2022-05-24)
Alzheimer’s disease (AD) has been associated with cardiovascular and cerebrovascular risk factors (CVRFs) during middle
age and later and is frequently accompanied by cerebrovascular pathology at death. An interaction ...
Progranulin mutations in clinical and neuropathological Alzheimer’s disease
(Alzheimers Dement., 2022-12-10)
Progranulin (GRN) mutations occur in frontotemporal lobar degeneration
(FTLD) and in Alzheimer’s disease (AD), often with TDP-43 pathology.
We determined the frequency of rs5848 and rare, pathogenic GRN mutations
in two ...
Neurovascular dysfunction and vascular amyloid accumulation as early events in Alzheimer's disease
(Metabolic Brain Disease, 2021-07)
Alzheimer's disease (AD) is clinically characterized by a progressive loss of cognitive functions and short-term memory. AD patients present two distinctive neuropathological lesions: neuritic plaques and neurofibrillary ...