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Autophagy: A key regulator of homeostasis and disease: an overview of molecular mechanisms and modulators
(Cells., 2022-08-22)
Autophagy is a highly conserved lysosomal degradation pathway active at basal levels
in all cells. However, under stress conditions, such as a lack of nutrients or trophic factors, it
works as a survival mechanism that ...
Biomarker Candidates for Alzheimer’s Disease Unraveled through In Silico Differential Gene Expression Analysis
(Basel, 2022-05-07)
Alzheimer’s disease (AD) is neurodegeneration that accounts for 60–70% of dementia cases.
Symptoms begin with mild memory difficulties and evolve towards cognitive impairment. The
underlying risk factors remain primarily ...
A Novel Automatic Quantification Protocol for Biomarkers of Tauopathies in the Hippocampus and Entorhinal Cortex of Post-Mortem Samples Using an Extended Semi-Siamese U-Net
(Biology., 2022-07-28)
Efforts have been made to diagnose and predict the course of different neurodegenerative
diseases through various imaging techniques. Particularly tauopathies, where the tau polypeptide
is a key participant in molecular ...
What trauma patients need: the European dilemma
(European Journal of Trauma and Emergency Surgery, 2022-07-22)
There is a need for implementation and maturation of an inclusive trauma system in every country in Europe, with patient centered care by dedicated surgeons. This process should be initiated by physicians and medical ...
Characterization of lime mortar and plasters of Fortress Concepción de la Vega
(MatTech, 2022-06-10)
The arrival of Christopher Columbus in America stimulated the creation of new settlements in which the materials and construction
methods coming from Spain and those existing in the area were used. The first village built ...
Current status and challenges of stem cell treatment for Alzheimer’s disease
(Journal of Alzheimer’s Disease, 2021)
Neurodegenerative diseases called tauopathies, such as Alzheimer’s disease (AD), frontotemporal dementia, progressive supranuclear palsy, and Parkinson’s disease, among others, are characterized by the pathological processing ...
Intravenous tocilizumab in the management of rheumatoid arthritis: Clinical practice findings from a 6-month international, multicentre, observational study in Central America and the Caribbean
(Revista Colombiana de Reumatología, 2020)
Tocilizumab (TCZ), an interleukin-6 receptor-α inhibitor, is indicated in patients with moderate to severe rheumatoid arthritis with inadequate response to disease modifying drugs. ACT UP is a multinational project collecting ...
Decline in empathy levels and sex differences in medical students from the Caribbean
(Semantic Scholar., 2021)
Empathy is an important trait in the training of medical students, as it has been shown that it improves the doctor-patient relationship. To evaluate the decline of empathy levels and possible sex differences in undergraduate ...
Dust from the Sahara to the American Continent: health impacts
(Allergol Immunopathol (Madr)., 2021)
The Saharan Air Layer is a mass of hot, dry air laden with dust that forms over the Sahara and
moves towards the Atlantic Ocean. This air mass contains soil dust particles emitted by the
action of winds on the African ...
Identifying users’ requirements for emergency mapping team operations in small island developing states: Caribbean Perspective
(International Journal o f Geo-Information, 2021)
Small Island Developing States (SIDS) increasingly face natural hazards that overwhelm
their capacity to generate and share spatial-information to reduce human–economic losses. Under
such circumstances, the emergency ...